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KMID : 0380620100420040475
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Korean Journal of Food Science and Technology
2010 Volume.42 No. 4 p.475 ~ p.480
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Effects of Supercritical Fluid Marc Extracts from Actinidia polygama Max. on Inflammation and Atherosclerosis
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Yu Me-Hee
Chae In-Gyeong
Choi Jun-Hyeok
Choi Hee-Don
Im Hyo-Gwon
Yang Seun-Ah
Lee Jin-Ho
Lee In-Seon
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Abstract
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The fruit of Actinidia polygama, Mock-chun-ryo in Korea, has been used as traditional medicine for abdominal pain, rheumatic arthritis, and stroke. In a previous study, the ethanol extract of A. polygama Max. showed antiinflammatory activity in RAW 264.7 cells. In this study, we investigated the anti-inflammatory and anti-atherosclerosis effects of supercritical fluid marc extracts from A. polygama Max. Anti-inflammatory extracts were produced from supercritical fluid extraction of the silver vine under the following conditions; pressure, 1,500-4,500 psi, temperature 35-55oC and extraction time 1-2 hr. To evaluate the anti-inflammatory and anti-atherosclerotic effects of the extracts, we studied nitric oxide (NO), prostaglandin E2 (PGE2), and tumor necrosis factor-alpha (TNF-α) levels in RAW 264.7 cells and MMP-9 activity in human aortic smooth muscle cells (HASMC). The Marc 11 extract inhibited the production of NO, PGE2, and TNF-α by lipopolysaccharide in RAW 264.7 cells. Moreover, the marc 11 extract inhibited TNF-α-induced MMP-9 activity in HASMC. These results indicate that the Marc 11 extract of A. polygama Max. has the potential for use as an anti-atherosclerosis agent.
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KEYWORD
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Actinidia polygama Max., supercritical fluid extraction (SFE), marc extract, anti-inflammatory and antiatherosclerotic effect
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